A Triad of Highly Reduced, Linear Iron Nitrosyl Complexes: {FeNO} 8–10

Structure and Magnetic Properties of Trigonal Bipyramidal Iron Nitrosyl Complexes

Non-heme Fe(II) proteins form stable nitrosyl adducts. However, there are few synthetic examples of structurally characterized non-heme iron nitrosyl complexes, especially those that are coordinatively unsaturated. Presented herein is a series of non-heme {Fe-NO}7 complexes with trigonal bipyramidal coordination geometry. These complexes were synthesized with tripodal ligands derived from tris(...

Developing iron nitrosyl complexes as NO donor prodrugs.

A novel class of water-soluble iron nitrosyl complexes has been developed for use as NO donor prodrugs. To elaborate these NO prodrugs various water-soluble ligands were used such as P(CH2OH)3, 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane (PTA), 1,2-bis[bis(hydroxymethyl)phosphino]ethane (HMPE), 1,2-bis[bis(hydroxymethyl)phosphino]benzene (TMBz), cysteamine, cysteamine hydrochloride, L-cystein...

Nitrosyl and carbene iron complexes bearing a κ(3)-SNS thioamide pincer type ligand.

The previously reported monochelate iron complex with κ(3) SNS thioamide pincer ligand, 2,6-bis(N-2,6-bis(diphenylmethyl)-4-isopropylphenyliminothiolate)pyridine (L(DPM)), [Fe(THF)2(κ(3)-L(DPM))], gave novel complexes, [Fe(NHC)(κ(3)-L(DPM))] and [Fe(NO)2(κ(3)-L(DPM))], by substitution reactions with N-heterocyclic carbene (NHC) and NO molecules, respectively. The X-ray crystal structure of the ...

The Electron Transfer Chemistry of Nitrosyl Complexes

Generation of EPR-detectable nitrosyl-iron complexes in tumor target cells cocultured with activated macrophages.

After immunostimulation, murine macrophages oxidize L-arginine into nitric oxide (NO) which acts as an effector molecule. In this study, we attempted to establish whether activated macrophage-derived NO forms paramagnetic complexes in tumor target cells which do not express by themselves the L-arginine:NO pathway. Accordingly, murine L1210 leukemia cells were cocultivated with activated periton...